Randomised health services studies

Randomised health services studies (RHS) refers to research on health service effectiveness which use randomised design in interventions carried out in routine health care.

Randomized healthservices study of Human Papillomavirus-based management of low-grade cytological abnormalities

Human Papillomavirus (HPV)-based management of women with borderline (ASCUS) or mildly abnormal (CINI) cervical cytology has been extensively studied in the research setting. We wished to assess safety and healthcare resource use of a real-life healthcare policy using HPV triaging. All 15 outpatient clinics involved in the organized population-based screening program in Stockholm, Sweden screening program were randomized to either continue with prior policy (colposcopy of all women with ASCUS/CINI) or to implement a policy with HPV triaging and colposcopy only of HPV-positive women.

Lead researcher: Lena Dillner

Primary institution: Oncology Center, Karolinska Hospital, Stockholm, Sweden

Collaborating institutions: WHO HPV LabNet Global Reference Laboratory; Laboratory Medicine Skåne, Malmö, Sweden

 

Controlled randomised implementation of colorectal cancer screening using FOBT in Finland among 60-69 year old men and women

Random allocation to screening (faecal occult blood testing biannually) or control groups during implementation period 2004-2104.

Lead researcher: Nea Malila

Primary institution: Finnish Cancer Registry

 

Comparison of vaginal HPV self-test and flexible appointment to reach long-term non-attending women in organized cervical screening

Many cervical cancers occur among women who have not attended cervical screening. Strategies to reach non-attending women may improve the effectiveness of cervical screening programs. Aim: To compare the responses among long-term non-attending women to either i) HPV-testing of a self-collected vaginal sample, or ii) cytological screening with a flexible no-fee appointment for sampling at an outpatient clinic.

Lead researcher: Lotten Darlin

Primary institution: Kvinnokliniken Skane University Hospital, University of Lund

Collaborating institutions: Microbiology Skane University Hospital, University of Lund

 

Comparison of use of vaginal HPV self-test and offering flexible appointments as strategies to reach long-term non-attending women in organized cervical screening.

Lead researcher: Lotten Darlin

Primary institution: Kvinnokliniken Skane University Hospital, University of Lund

Collaborating institutions: Mikrobiology Malmö; University Hospital of Skane

 

PEGOSS, The impact of low-volume versus standard volume bowel preparation on the participation in primary screening colonoscopy: a randomized health services (RHS), comparative effectiveness research study

Standard-volume vs low-volume bowel preparations for screening colonoscopy.

Lead researcher: Jaroslaw Regula

Primary institution: The Medical Centre for Postgraduate Education, Warsaw, Poland

Collaborating institutions: The Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

 

Randomized Implementation and Evaluation of Changes in the Norwegian Cervical Cancer Screening Program

A randomized health services evaluation to compare the impact of primary high-risk human papillomavirus (hrHPV) testing every 5 years versus liquid-based cytology (LBC) every 3 years in the prevention of cervical cancer through early detection and treatment of its immediate precursors, cervical intraepithelial neoplasia grade 3 (CIN3) and adenocarcinoma in situ (AIS), in the Norwegian Cervical Cancer Screening Program.

Lead researcher:Stefan Lönnberg

Primary institution: The Cancer Registry of Norway

 

Polish Colonoscopy Screening Program: a randomized health services (RHS) study

Immediate vs postponed (5 years) screening colonoscopy in people invited by letter.

Lead researcher: Jaroslaw Regula

Primary institution: The Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

Collaborating institutions: The Medical Centre for Postgraduate Education, Warsaw, Poland

 

Effectiveness of electronic quality assurance (e-Gastronet) in endoscopy screening for colorectal cancer – a randomized controlled health services study

Free choice of form of patient feedback (paper questionnaire, automated telephone response system or online questionnaire) to screening endoscopy.

Lead researcher: Jaroslaw Regula

Primary institution: The Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

Collaborating institutions: University of Oslo, Norway

 

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Additional information on randomized health services studies

Randomized health services studies (RHS) (xlsx)