Home » Publications

Publications

Scientific publications

1356613 1 biosocieties 15 date desc 1 title 4076 /assets/modules/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22LWNM9YHU%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Leenen%20et%20al.%22%2C%22parsedDate%22%3A%222026-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLeenen%2C%20R.C.A.%20et%20al.%20%282026%29%20Prostate%20Cancer%20Mortality%20in%20Men%20not%20Attending%20a%20Population-based%20Screening%20Program%3A%20The%20%26%23x201C%3BGood%26%23x201D%3B%2C%20the%20%26%23x201C%3BBad%26%23x201D%3B%2C%20and%20the%20%26%23x201C%3BUgly%26%23x201D%3B%20After%2020-yr%20Follow-up%20in%20the%20European%20Randomised%20study%20of%20Screening%20for%20Prostate%20Cancer.%20European%20Urology%20Open%20Science%2091%2C%2059%26%23x2013%3B66.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prostate%20Cancer%20Mortality%20in%20Men%20not%20Attending%20a%20Population-based%20Screening%20Program%3A%20The%20%27Good%27%2C%20the%20%27Bad%27%2C%20and%20the%20%27Ugly%27%20After%2020-yr%20Follow-up%20in%20the%20European%20Randomised%20study%20of%20Screening%20for%20Prostate%20Cancer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ren%5Cu00e9e%20C.%20A.%22%2C%22lastName%22%3A%22Leenen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esm%5Cu00e9e%20F.%20H.%22%2C%22lastName%22%3A%22Mulder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastiaan%22%2C%22lastName%22%3A%22Remmers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivo%20I.%22%2C%22lastName%22%3A%22de%20Vos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirsi%22%2C%22lastName%22%3A%22Talala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonas%22%2C%22lastName%22%3A%22Hugosson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecka%22%2C%22lastName%22%3A%22Arnsrud-Godtman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elly%20Den%22%2C%22lastName%22%3A%22Hond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnauld%22%2C%22lastName%22%3A%22Villers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Pionas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luis%22%2C%22lastName%22%3A%22Llane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcos%22%2C%22lastName%22%3A%22Lujan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Gorini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donella%22%2C%22lastName%22%3A%22Puliti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maciej%22%2C%22lastName%22%3A%22Kwiatkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Wyler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Bangma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fritz%20H.%22%2C%22lastName%22%3A%22Schroder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anssi%22%2C%22lastName%22%3A%22Auvinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%20J.%22%2C%22lastName%22%3A%22Roobol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ERSPC%20Study%20Group%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVE%3A%20Nonattendance%20can%20substantially%20decrease%20the%20effectiveness%20of%20existing%20and%20potential%20future%20population-based%20screening%20programmes%20for%20%28prostate%29%20cancer.%20We%20evaluated%20the%20long-term%20association%20between%20nonattendance%20and%20prostate%20cancer-specific%20mortality%20%28PCSM%29%20in%20the%20European%20Randomised%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29%2C%20with%20up%20to%2020%5Cu00a0yr%20of%20follow-up.%5CnMETHODS%3A%20This%20secondary%20analysis%20included%20161%5Cu00a0380%20men%20aged%2055-69%5Cu00a0yr%20randomised%20to%20receive%20invitations%20for%20Prostate-specific%20antigen-based%20%28PSA%29-based%20screening%20%28n%5Cu00a0%3D%5Cu00a072%5Cu00a0460%2C%20screening%20arm%20%5BSA%5D%29%20or%20to%20the%20control%20arm%20%28CA%29%20%28n%5Cu00a0%3D%5Cu00a088%2C920%29%20across%20seven%20ERSPC%20centres.%20Within%20the%20SA%2C%20men%20were%20classified%20as%20screening%20never-attenders%20%28no%20attendance%20at%20any%20screening%20round%29%20or%20screening%20ever-attenders%20%28attended%20at%20least%20one%20screening%20round%29.%20The%20primary%20endpoint%20was%20PCSM.%20Cumulative%20incidence%20of%20PCSM%20was%20calculated%20using%20competing%20risk%20analysis%2C%20accounting%20for%20death%20from%20other%20causes%20as%20a%20competing%20event.%20Poisson%20regression%20was%20used%20to%20estimate%20rate%20ratios%20%28RR%29%20of%20cumulative%20PCSM%20between%20three%20groups%3A%20screening%20never-attenders%2C%20ever-attenders%2C%20and%20CA.%5CnKEY%20FINDINGS%20AND%20LIMITATIONS%3A%20Of%20the%2072%5Cu00a0460%20men%20in%20the%20SA%2C%2012%2C401%20%2817%25%29%20were%20defined%20as%20never-attenders.%20At%2020%5Cu00a0yr%2C%20the%20cumulative%20PCSM%20was%201.4%25%20%2895%25%20confidence%20interval%20%5BCI%5D%2C%201.2-1.6%29%20among%20never-attenders%2C%201.2%25%20%2895%25%20CI%2C%201.2-1.3%29%20in%20the%20CA%2C%20and%201.0%25%20%2895%25%20CI%2C%200.9-1.0%29%20in%20ever-attenders.%20For%20PCSM%2C%20we%20observed%20an%20RR%20of%201.39%20%2895%25%20CI%2C%201.2-1.6%3B%20p%5Cu00a0%26lt%3B%5Cu00a00.001%29%20for%20never-attenders%20compared%20to%20the%20CA%2C%20while%20for%20ever-attenders%20compared%20to%20the%20CA%2C%20we%20observed%20an%20RR%20of%200.77%20%2895%25%20CI%2C%200.69-0.85%3B%20p%5Cu00a0%26lt%3B%5Cu00a00.001%29.%20Data%20on%20determinants%20of%20attendance%20are%20lacking.%5CnCONCLUSIONS%20AND%20CLINICAL%20IMPLICATIONS%3A%20Men%20randomised%20to%20the%20SA%20but%20who%20never%20attended%20had%20higher%20observed%20PCSM%20than%20men%20in%20the%20CA%20who%20were%20not%20offered%20screening.%20Conversely%2C%20men%20in%20the%20SA%20who%20attended%20screening%20had%20lower%20observed%20PCSM%20than%20men%20in%20the%20CA%2C%20with%20a%20larger%20observed%20difference%20than%20that%20reported%20in%20prior%20intention-to-screen%20analyses.%20Trial%20registration%3A%20ISRCTN49127736.%22%2C%22date%22%3A%222026-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.euros.2026.06.009%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242571431%22%2C%22PMCID%22%3A%22PMC13452280%22%2C%22ISSN%22%3A%222666-1683%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A33%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22UP8KQ554%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bhargava%20et%20al.%22%2C%22parsedDate%22%3A%222026-08-22%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBhargava%2C%20S.%20et%20al.%20%282026%29%20Interventions%20to%20increase%20breast%20cancer%20screening%20attendance%20among%20immigrants%3A%20a%20cross-sectional%20international%20survey.%20Journal%20of%20Public%20Health%2C%20fdag061.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Interventions%20to%20increase%20breast%20cancer%20screening%20attendance%20among%20immigrants%3A%20a%20cross-sectional%20international%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sameer%22%2C%22lastName%22%3A%22Bhargava%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Vigdis%22%2C%22lastName%22%3A%22Heimseter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunhild%22%2C%22lastName%22%3A%22Mangerud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eli%20Nina%20H%5Cu00f8lleland%22%2C%22lastName%22%3A%22Eikefjord%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%20Dyrstad%22%2C%22lastName%22%3A%22Hartvigsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Livia%22%2C%22lastName%22%3A%22Giordano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veli-Matti%22%2C%22lastName%22%3A%22Partanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marthe%22%2C%22lastName%22%3A%22Larsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silje%22%2C%22lastName%22%3A%22Sagstad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%22%2C%22lastName%22%3A%22Natale-Pereira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arlinda%22%2C%22lastName%22%3A%22Ruco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%22%2C%22lastName%22%3A%22Bunzeluk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Mette%20Fl%5Cu00f8e%22%2C%22lastName%22%3A%22Hvass%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Solveig%22%2C%22lastName%22%3A%22Hofvind%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Immigrant%20populations%20demonstrate%20lower%20attendance%20in%20organized%20breast%20cancer%20screening%20programs%20than%20non-immigrants.%20Evidence%20on%20interventions%20to%20increase%20attendance%2C%20and%20their%20effectiveness%2C%20remains%20limited.%20We%20aimed%20to%20map%20interventions%20implemented%20in%20nationally%20or%20regionally%20organized%20screening%20programs%20to%20enhance%20immigrants%26%23039%3B%20attendance%20and%20to%20assess%20the%20extent%20of%20their%20systematic%20evaluation.%5CnMETHODS%3A%20We%20conducted%20a%20survey%20using%20an%20electronic%20questionnaire%20distributed%20through%20the%20International%20Cancer%20Screening%20Network%20mailing%20list%20and%20snowball%20sampling%20to%20identify%20interventions%20improving%20breast%20cancer%20screening%20attendance%20among%20immigrant%20populations.%20Twenty-seven%20screening%20programs%20participated.%20As%20the%20number%20of%20eligible%20programs%20reached%20was%20unknown%2C%20response%20rate%20could%20not%20be%20calculated.%20Findings%20should%20be%20considered%20descriptive%20rather%20than%20representative%20of%20international%20practice.%20Data%20were%20analyzed%20using%20descriptive%20statistics.%5CnRESULTS%3A%20Most%20programs%20%2870%25%2C%2019%5C%2F27%29%20lacked%20routine%20systems%20to%20monitor%20immigrants%26%23039%3B%20attendance.%20Across%2010%20predefined%20categories%2C%20111%20interventions%20were%20reported.%20Of%20these%2C%2023%25%20%2825%5C%2F111%29%20had%20been%20evaluated%2C%20and%209%25%20%2810%5C%2F111%29%20were%20reported%20by%20respondents%20to%20have%20increased%20attendance.%20The%20most%20frequently%20implemented%20interventions%20were%20translated%20materials%20%2870%25%2C%2019%5C%2F27%29%2C%20public%20advertisements%20%2852%25%2C%2014%5C%2F27%29%2C%20and%20collaboration%20with%20voluntary%20organizations%20%2852%25%2C%2014%5C%2F27%29.%20Evaluation%20rates%20varied%3A%2016%25%20%283%5C%2F19%29%20for%20translated%20materials%2C%2021%25%20%283%5C%2F14%29%20for%20public%20advertisements%2C%20and%2050%25%20%287%5C%2F14%29%20for%20voluntary%20sector%20partnerships.%5CnCONCLUSIONS%3A%20Considerable%20variation%20exists%20in%20data%20availability%20on%20immigrants%26%23039%3B%20attendance.%20Few%20interventions%20have%20been%20rigorously%20evaluated.%20Strengthening%20monitoring%20systems%20and%20generating%20evidence%20are%20essential%20to%20promote%20equitable%20screening%20attendance%2C%20although%20current%20findings%20are%20partly%20based%20on%20self-reported%20data%20and%20should%20be%20interpreted%20with%20caution.%22%2C%22date%22%3A%222026-08-22%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fpubmed%5C%2Ffdag061%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242631920%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221741-3850%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A33%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22USMHU5PM%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Muhonen%20et%20al.%22%2C%22parsedDate%22%3A%222026-08-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMuhonen%2C%20E.%20et%20al.%20%282026%29%20Incidence%20Trends%20of%20Colorectal%20Cancer%20by%20Social%20and%20Behavioral%20Factors-A%20Pooled%20Cohort%20Study.%20International%20Journal%20of%20Cancer.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Incidence%20Trends%20of%20Colorectal%20Cancer%20by%20Social%20and%20Behavioral%20Factors-A%20Pooled%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilia%22%2C%22lastName%22%3A%22Muhonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heidi%22%2C%22lastName%22%3A%22Ryyn%5Cu00e4nen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%20G.%22%2C%22lastName%22%3A%22Eriksson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tommi%22%2C%22lastName%22%3A%22H%5Cu00e4rk%5Cu00e4nen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pekka%22%2C%22lastName%22%3A%22Jousilahti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Knekt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seppo%22%2C%22lastName%22%3A%22Koskinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Satu%22%2C%22lastName%22%3A%22M%5Cu00e4nnist%5Cu00f6%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ossi%22%2C%22lastName%22%3A%22Rahkonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maarit%20A.%22%2C%22lastName%22%3A%22Laaksonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janne%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanna%22%2C%22lastName%22%3A%22Lappi-Heikkinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22METCA%20Study%20Group%22%7D%5D%2C%22abstractNote%22%3A%22Colorectal%20cancer%20%28CRC%29%20represents%20more%20than%2010%25%20of%20the%20global%20cancer%20burden.%20Unlike%20in%20some%20other%20cancers%2C%20no%20single%20risk%20factor%20accounts%20for%20most%20CRC%20cases.%20Despite%20the%20well-studied%20overall%20incidence%20trend%20of%20CRC%2C%20little%20information%20is%20available%20on%20risk%20factor-specific%20incidence%20trends%20of%20CRC.%20This%20study%20aims%20to%20evaluate%20the%20rarely%20studied%20incidence%20trends%20of%20CRC%20in%20males%20and%20females%20with%20variable%20levels%20of%20exposure%20to%20specific%20risk%20factors%2C%20including%20education%20level%2C%20cigarette%20smoking%2C%20alcohol%20consumption%2C%20physical%20inactivity%2C%20and%20body%20mass%20index%20%28BMI%29.%20We%20used%20Finnish%20pooled%20cohort%20data%20from%20seven%20cohorts%20linked%20to%20the%20population-based%20Finnish%20Cancer%20Registry.%20The%20pooled%20data%20included%20224%2C048%20subjects%2C%20of%20whom%202006%20were%20diagnosed%20with%20CRC.%20CRC%20incidence%20adjusted%20for%20known%20risk%20factors%20increased%20annually%20by%201.7%25%20in%20males%20and%201.0%25%20in%20females.%20In%20risk%20factor-stratified%20analysis%2C%20the%20average%20annual%20percentage%20increase%20in%20CRC%20incidence%20was%20especially%20high%20in%20current%20male%20smokers.%20This%20study%20further%20strengthens%20the%20evidence%20that%20living%20with%20overweight%20or%20obesity%2C%20having%20a%20tall%20body%20height%2C%20or%20living%20with%20diabetes%20mellitus%20%28DM%29%20associates%20with%20an%20increased%20risk%20of%20CRC.%20Cigarette%20smoking%20was%20associated%20with%20an%20increased%20CRC%20risk%20in%20males%2C%20while%20heavy%20alcohol%20consumption%20was%20associated%20with%20an%20increased%20risk%20in%20females.%20In%20this%20study%2C%20education%20level%20or%20physical%20inactivity%20were%20not%20statistically%20significant%20risk%20factors%20for%20CRC.%20Our%20findings%20highlight%20the%20need%20for%20effective%20public%20health%20strategies%2C%20with%20special%20emphasis%20on%20preventing%20overweight%2C%20obesity%2C%20and%20smoking%20along%20with%20other%20modifiable%20lifestyle%20factors%20known%20to%20affect%20CRC%20risk.%22%2C%22date%22%3A%222026-08-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fijc.70656%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242552866%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221097-0215%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A33%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22Q6HAK9VP%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kallionp%5Cu00e4%5Cu00e4%20et%20al.%22%2C%22parsedDate%22%3A%222026-08-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKallionp%26%23xE4%3B%26%23xE4%3B%2C%20R.A.%20et%20al.%20%282026%29%20Cancer%20incidence%20and%20the%20risk%20for%20multiple%20primary%20cancers%20in%20neurofibromatosis%20type%201.%20Journal%20of%20the%20National%20Cancer%20Institute%2C%20djag269.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20incidence%20and%20the%20risk%20for%20multiple%20primary%20cancers%20in%20neurofibromatosis%20type%201%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roope%20A.%22%2C%22lastName%22%3A%22Kallionp%5Cu00e4%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sirkku%22%2C%22lastName%22%3A%22Peltonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elina%22%2C%22lastName%22%3A%22Uusitalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jussi%22%2C%22lastName%22%3A%22Lepp%5Cu00e4virta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mari%22%2C%22lastName%22%3A%22Hell%5Cu00e9n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niina%22%2C%22lastName%22%3A%22Loponen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matti%22%2C%22lastName%22%3A%22Rantanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tommi%22%2C%22lastName%22%3A%22Frang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lotta%22%2C%22lastName%22%3A%22Vihervaara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heli%22%2C%22lastName%22%3A%22Yl%5Cu00e4-Outinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janne%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minna%22%2C%22lastName%22%3A%22P%5Cu00f6yh%5Cu00f6nen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juha%22%2C%22lastName%22%3A%22Peltonen%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Neurofibromatosis%201%20%28NF1%29%20is%20a%20cancer%20predisposition%20syndrome%20caused%20by%20pathogenic%20variants%20of%20the%20NF1%20gene.%20Here%2C%20we%20analyze%20the%20incidence%20and%20risk%20of%20cancer%20and%20especially%20the%20risk%20of%20multiple%20primary%20cancers%20in%20individuals%20with%20NF1.%5CnMETHODS%3A%20The%20previously%20established%20Finnish%20NF1%20cohort%20was%20extended%20to%20include%201%2C811%20individuals%20with%20verified%20NF1%20and%20followed%20up%20using%20the%20nationwide%20Finnish%20Cancer%20Registry%20for%2030%2C612%20person-years%20over%201987-2020.%20Standardized%20incidence%20ratios%20%28SIRs%29%20were%20used%20to%20analyze%20cancer%20incidence.%5CnRESULTS%3A%20A%20total%20of%20296%20first%20primary%20cancers%20occurred%20in%20individuals%20with%20NF1%20during%20the%20follow-up%2C%20yielding%20an%20SIR%20of%204.92%20%2895%25%20CI%204.38-5.52%29.%20The%20SIR%20was%204.30%20%2895%25%20CI%203.27-5.54%29%20for%20second%20primary%20cancers%20with%2059%20cancers%20observed.%20Therefore%2C%20the%20history%20of%20first%20primary%20cancer%20did%20not%2C%20in%20general%2C%20indicate%20altered%20risk%20for%20second%20primary%20cancer%20among%20individuals%20with%20NF1%20%28P%3D0.377%29.%20Overall%2C%20NF1%20was%20associated%20with%20a%20steadily%20increasing%20cumulative%20risk%20for%20cancer%20throughout%20the%20lifetime.%20Women%20with%20NF1%20had%20a%2020.9%25%20%2895%25%20CI%2015.9-27.4%25%29%20lifetime%20risk%20for%20breast%20cancer%20with%20significantly%20increased%20incidence%20at%20ages%20%26lt%3B50%20and%20%5Cu226550%20years%20%28SIRs%204.90%2C%2095%25%20CI%202.99-7.56%20and%202.67%2C%2095%25%20CI%201.76-3.89%2C%20respectively%29.%5CnCONCLUSION%3A%20The%20history%20of%20a%20prior%20cancer%20does%20not%20predict%20the%20overall%20future%20risk%20for%20cancer%20in%20NF1.%20Nevertheless%2C%20the%20estimates%20are%20consistent%20with%20some%20subpopulations%20having%20an%20increased%20risk%20for%20multiple%20cancers.%20Regarding%20breast%20cancer%20predisposition%2C%20the%20results%20confirm%20NF1%20as%20a%20moderate-risk%20gene%20linked%20to%20increased%20incidence%20across%20all%20ages%2C%20i.e.%2C%20not%20only%20in%20young%20women.%22%2C%22date%22%3A%222026-08-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fjnci%5C%2Fdjag269%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242549890%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221460-2105%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A32%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22GMJD38Z2%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kyr%5Cu00f6nlahti%20et%20al.%22%2C%22parsedDate%22%3A%222026-07-30%22%2C%22numChildren%22%3A5%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKyr%5Cu00f6nlahti%2C%20A.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42530286%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260813002335%26amp%3Bv%3D2.20.1%26%23039%3B%26gt%3BEstimated%20number%20of%20children%20affected%20by%20paternal%20cancer%20diagnosis%20and%20death%20in%20Finland%20during%201970-2022%3A%20a%20population-based%20registry%20study%26lt%3B%5C%2Fa%26gt%3B.%20Acta%20oncologica%20%28Stockholm%2C%20Sweden%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Estimated%20number%20of%20children%20affected%20by%20paternal%20cancer%20diagnosis%20and%20death%20in%20Finland%20during%201970-2022%3A%20a%20population-based%20registry%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anniina%22%2C%22lastName%22%3A%22Kyr%5Cu00f6nlahti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eetu%22%2C%22lastName%22%3A%22M%5Cu00e4kinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tea%22%2C%22lastName%22%3A%22Lallukka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janne%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BActa%20Oncol.%202026%20Jul%2030%3B65%3A661-667.%20doi%3A%2010.2340%5C%2F1651-226X.2026.45653.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BBACKGROUND%20AND%20PURPOSE%3A%20Parental%20cancer%20effects%20millions%20of%20children%20worldwide.%20We%20estimated%20the%20number%20of%20children%20influenced%20by%20paternal%20cancer%20and%20paternal%20orphans%2C%20and%20examined%20changes%20in%20their%20numbers%20and%20annual%20rates%20over%20time%2C%20with%20a%20focus%20on%20time%20trends%20and%20the%20influence%20of%20cancer%20type.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BPATIENTS%20AND%20METHODS%3A%20Male%20cancer%20patients%20aged%20%5Cu226515%20years%2C%20diagnosed%20since%201953%2C%20were%20identified%20from%20the%20Finnish%20Cancer%20Registry.%20Cancer%20deaths%20and%20information%20on%20live%20births%20were%20obtained%20from%20Statistics%20Finland.%20Annual%20number%20of%20new%20children%20and%20prevalent%20children%20whose%20father%20was%20diagnosed%20with%20cancer%20and%20the%20annual%20number%20of%20new%20orphans%20and%20prevalent%20orphans%20due%20to%20paternal%20cancer%20death%20for%201970-2022%20were%20estimated%20indirectly%20by%20combining%20cancer%20incidence%20and%20mortality%20data%20with%20population-level%20fertility%20rates.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BRESULTS%3A%20The%20estimated%20age-standardized%20rate%20of%20new%20children%20with%20paternal%20cancer%20increased%20from%2096%5C%2F100%2C000%20children%20in%201970-1974%20to%20163%5C%2F100%2C000%20in%202017-2021.%20The%20annual%20rate%20of%20new%20paternal%20orphans%20decreased%20from%2056%5C%2F100%2C000%20in%201970-1974%20to%2035%5C%2F100%2C000%20in%202017-2021.%20The%20rate%20of%20new%20children%20increased%201.1%25%20per%20year%20while%20the%20rate%20of%20new%20orphans%20decreased%201.1%25%20in%201970-2021.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BINTERPRETATION%3A%20Although%20the%20number%20of%20paternal%20orphans%20is%20decreasing%20due%20to%20improved%20cancer%20survival%2C%20the%20number%20of%20children%20influenced%20by%20paternal%20cancer%20is%20rising%20reflecting%20the%20increasing%20cancer%20incidence%20and%20resulting%20in%20more%20children%20vulnerable%20to%20the%20harmful%20effects%20of%20paternal%20cancer.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42530286%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260813002335%26amp%3Bv%3D2.20.1%26quot%3B%26gt%3B42530286%26lt%3B%5C%2Fa%26gt%3B%20%7C%20PMC%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2FPMC13430636%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260813002335%26amp%3Bv%3D2.20.1%26quot%3B%26gt%3BPMC13430636%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2340%5C%2F1651-226X.2026.45653%26quot%3B%26gt%3B10.2340%5C%2F1651-226X.2026.45653%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-07-30%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.2340%5C%2F1651-226X.2026.45653%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42530286%5C%2F%3Futm_source%3DFirefox%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26fc%3D20241001055739%26ff%3D20260813002335%26v%3D2.20.1%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A32%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22HCCFKU9E%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pukkala%20et%20al.%22%2C%22parsedDate%22%3A%222026-07-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPukkala%2C%20E.%20et%20al.%20%282026%29%20Cancer%20incidence%20and%20mortality%20among%20persons%20in%20the%20Finnish%20Register%20of%20Employees%20Exposed%20to%20Carcinogens%2C%201979-2018.%20Annals%20of%20Work%20Exposures%20and%20Health%2070%286%29%2C%20wxag062.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20incidence%20and%20mortality%20among%20persons%20in%20the%20Finnish%20Register%20of%20Employees%20Exposed%20to%20Carcinogens%2C%201979-2018%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eero%22%2C%22lastName%22%3A%22Pukkala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elli%22%2C%22lastName%22%3A%22Hirvonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salla%22%2C%22lastName%22%3A%22Toikkanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanni%22%2C%22lastName%22%3A%22Uuksulainen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomas%22%2C%22lastName%22%3A%22Tanskanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiina%22%2C%22lastName%22%3A%22Santonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tuula%22%2C%22lastName%22%3A%22Liukkonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanna%22%2C%22lastName%22%3A%22Lappi-Heikkinen%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20It%20has%20been%20estimated%20that%202%25%20to%208%25%20of%20cancers%20in%20high-income%20countries%20are%20linked%20to%20carcinogenic%20exposures%20in%20workplaces.%20In%20Finland%2C%20employers%20are%20obliged%20by%20law%20to%20provide%20data%20annually%20on%20selected%20carcinogens%20and%20carcinogenic%20working%20processes%20to%20the%20Finnish%20Register%20of%20Employees%20Exposed%20to%20Carcinogens%20%28ASA%29.%20In%20this%20study%2C%20we%20expand%20the%20follow-up%20period%20of%20a%20previous%20study%20on%20cancer%20incidence%20in%20exposed%20employees%20by%2016%20years%20and%20add%20estimates%20of%20cancer%20mortality.%5CnMETHODS%3A%20The%20study%20population%20included%20all%20142%2C204%20workers%20registered%20in%20ASA%20from%201979%20to%202018.%20For%20the%20cancer%20follow-up%2C%20the%20data%20were%20linked%20to%20the%20Finnish%20Cancer%20Registry.%20To%20compare%20the%20incidence%20and%20mortality%20with%20those%20of%20the%20Finnish%20general%20population%2C%20we%20estimated%20standardized%20incidence%20ratios%20%28SIRs%29%20and%20standardized%20mortality%20ratios.%5CnRESULTS%3A%20A%20total%20of%2012%2C687%20cancer%20cases%20and%203%2C640%20cancer%20deaths%20were%20reported%20among%20ASA%20workers%20over%20time%20by%20the%20end%20of%202019.%20In%20the%20entire%20ASA%20cohort%2C%20the%20all-site%20cancer%20incidence%20was%20similar%20to%20the%20general%20population%20%28SIR%200.98%2C%2095%25%20confidence%20interval%20%5BCI%5D%200.96%20to%200.99%29.%20Persons%20exposed%20to%20asbestos%20showed%20an%20excess%20incidence%20of%20mesothelioma%20%28SIR%201.80%2C%20CI%201.17%20to%202.66%29%20and%20small%20cell%20carcinoma%20of%20the%20lungs%20%28SIR%201.32%2C%20CI%201.02%20to%201.67%29.%20Exposure%20to%20hardwood%20dust%20%28oak%20and%20beech%29%20was%20associated%20with%20an%20increased%20incidence%20of%20nasal%20cancer%20%288.69%2C%201.05%20to%2031.4%29%2C%20specifically%20nasal%20adenocarcinoma%20%28SIR%2058.3%2C%20CI%207.06%20to%20211%29.%20Increased%20mortality%20was%20observed%20for%20exposure-cancer%20combinations%20that%20also%20showed%20increased%20cancer%20incidence.%5CnCONCLUSIONS%3A%20This%20study%20demonstrated%20the%20strongest%20confirmed%20associations%20between%20occupational%20exposures%20and%20cancer.%20The%20absence%20of%20many%20known%20exposure-cancer%20associations%20may%20point%20to%20low%20levels%20of%20exposure%20among%20workers%20registered%20in%20ASA%20or%20to%20small%20effect%20sizes%20of%20the%20agents%20investigated.%22%2C%22date%22%3A%222026-07-17%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fannweh%5C%2Fwxag062%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%2242600110%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222398-7316%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-08-24T06%3A33%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22YB9HWD8N%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tarkiainen%20et%20al.%22%2C%22parsedDate%22%3A%222026-07-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTarkiainen%2C%20L.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42456540%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260729050333%26amp%3Bv%3D2.20.0%26%23039%3B%26gt%3BAlcohol%20consumption%20increased%20the%20risk%20of%20prostate%20cancer%3A%20A%20Finnish%20pooled%20population-based%20cohort%20study%26lt%3B%5C%2Fa%26gt%3B.%20European%20journal%20of%20cancer%20%28Oxford%2C%20England%20%3A%201990%29.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Alcohol%20consumption%20increased%20the%20risk%20of%20prostate%20cancer%3A%20A%20Finnish%20pooled%20population-based%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leevi%22%2C%22lastName%22%3A%22Tarkiainen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanna%22%2C%22lastName%22%3A%22Lappi-Heikkinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heidi%22%2C%22lastName%22%3A%22Ryyn%5Cu00e4nen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maarit%20A.%22%2C%22lastName%22%3A%22Laaksonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Knekt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Satu%22%2C%22lastName%22%3A%22M%5Cu00e4nnist%5Cu00f6%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tommi%22%2C%22lastName%22%3A%22H%5Cu00e4rk%5Cu00e4nen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pekka%22%2C%22lastName%22%3A%22Jousilahti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seppo%22%2C%22lastName%22%3A%22Koskinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%20G.%22%2C%22lastName%22%3A%22Eriksson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sirpa%22%2C%22lastName%22%3A%22Hein%5Cu00e4vaara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ossi%22%2C%22lastName%22%3A%22Rahkonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janne%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22METCA%20Study%22%2C%22lastName%22%3A%22Group%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BEur%20J%20Cancer.%202026%20Jul%209%3B245%3A116941.%20doi%3A%2010.1016%5C%2Fj.ejca.2026.116941.%20Online%20ahead%20of%20print.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BBACKGROUND%3A%20Modifiable%20risk%20factors%20for%20the%20incidence%20of%20prostate%20cancer%20%28PCa%29%20have%20not%20been%20convincingly%20established.%20Consequently%2C%20the%20evidence%20on%20the%20relationship%20between%20alcohol%20consumption%20and%20the%20incidence%20of%20PCa%20has%20remained%20inconclusive.%20Our%20aim%20was%20to%20assess%20the%20association%20between%20alcohol%20consumption%20and%20the%20incidence%20of%20PCa.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BMETHODS%3A%20We%20used%20data%20from%20six%20Finnish%20population-based%20cohort%20studies%20with%20data%20collected%20between%201972%20and%202015%20that%20included%20a%20total%20of%2082%2C570%20male%20participants.%20Information%20on%20participants%26%23039%3B%20alcohol%20consumption%2C%20BMI%2C%20height%2C%20smoking%20status%2C%20education%2C%20and%20physical%20activity%20were%20harmonized%20and%20categorized.%20Regarding%20alcohol%20consumption%2C%20the%20men%20were%20categorized%20into%20non-users%20and%20into%20light%2C%20moderate%2C%20and%20heavy%20users.%20Bayesian%20hierarchical%20Poisson%20regression%20was%20used%20to%20model%20the%20association%20between%20risk%20factors%20and%20PCa%20incidence.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BFINDINGS%3A%20Alcohol%20consumption%2C%20among%20light%2C%20moderate%2C%20and%20heavy%20consumers%2C%20was%20associated%20with%20an%20increased%20incidence%20of%20PCa%20when%20compared%20to%20non-drinkers.%20The%20hazard%20ratio%20%28HR%29%20of%20PCa%20incidence%20was%201.18%20%2895%25%20CI%201.02%20-%201.36%29%20for%20light%20alcohol%20consumers%2C%201.20%20%2895%25%20CI%201.03%20-%201.40%29%20for%20moderate%20consumers%2C%20and%201.32%20%2895%25%20CI%201.08%20-%201.60%29%20for%20heavy%20consumers.%20Additionally%2C%20there%20was%20some%20evidence%20of%20a%20dose-response%20relationship%20between%20alcohol%20consumption%20and%20the%20incidence%20of%20PCa.%20None%20of%20the%20other%20risk%20factors%20studied%20were%20significantly%20associated%20with%20the%20incidence%20of%20PCa.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BINTERPRETATION%3A%20Our%20results%20provide%20further%20evidence%20of%20an%20association%20between%20alcohol%20consumption%20and%20an%20increased%20incidence%20of%20PCa.%20This%20potential%20relationship%20in%20the%20etiology%20of%20prostate%20cancer%20may%20offer%20essential%20information%20for%20preventive%20efforts.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42456540%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260729050333%26amp%3Bv%3D2.20.0%26quot%3B%26gt%3B42456540%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ejca.2026.116941%26quot%3B%26gt%3B10.1016%5C%2Fj.ejca.2026.116941%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-07-15%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ejca.2026.116941%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42456540%5C%2F%3Futm_source%3DFirefox%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26fc%3D20241001055739%26ff%3D20260729050333%26v%3D2.20.0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-07-29T09%3A03%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22NJJENYPB%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pasanen%20et%20al.%22%2C%22parsedDate%22%3A%222026-07-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPasanen%2C%20N.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42400346%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260707032721%26amp%3Bv%3D2.20.0%26%23039%3B%26gt%3BCancer%20detection%20in%20the%20European%20Randomised%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29%26lt%3B%5C%2Fa%26gt%3B.%20BJU%20international.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20detection%20in%20the%20European%20Randomised%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niko%22%2C%22lastName%22%3A%22Pasanen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirsi%22%2C%22lastName%22%3A%22Talala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastiaan%22%2C%22lastName%22%3A%22Remmers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Teuvo%20L.%20J.%22%2C%22lastName%22%3A%22Tammela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonas%22%2C%22lastName%22%3A%22Hugosson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecka%20Arnsrud%22%2C%22lastName%22%3A%22Godtman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kimmo%22%2C%22lastName%22%3A%22Taari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Bangma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elly%20Den%22%2C%22lastName%22%3A%22Hond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vera%22%2C%22lastName%22%3A%22Nelen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Wyler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maciej%22%2C%22lastName%22%3A%22Kwiatkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donella%22%2C%22lastName%22%3A%22Puliti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Gorini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luis%22%2C%22lastName%22%3A%22Gonz%5Cu00e0lez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcos%22%2C%22lastName%22%3A%22Lujan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%20J.%22%2C%22lastName%22%3A%22Roobol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anssi%22%2C%22lastName%22%3A%22Auvinen%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BBJU%20Int.%202026%20Jul%204.%20doi%3A%2010.1111%5C%2Fbju.70380.%20Online%20ahead%20of%20print.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BOBJECTIVES%3A%20To%20provide%20a%20comprehensive%20analysis%20regarding%20outcomes%20of%20repeated%20screening%20and%20detection%20of%20low-grade%20versus%20high-grade%20cancer%20from%20the%20European%20Randomised%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BMATERIALS%20AND%20METHODS%3A%20This%20study%20analysed%20men%20aged%2055-69%20years%20at%20random%20across%20the%20ERSPC%20trial%20centres%20except%20France.%20Men%20in%20the%20screening%20arm%20were%20classified%20as%20ever-attenders%20%28who%20attended%20at%20least%20one%20screening%20cycle%29%20or%20non-attenders%20%28who%20did%20not%20attend%20a%20specific%20screening%20cycle%29.%20Cancer%20detection%20rates%20%28CDRs%29%20were%20calculated%20by%20age%20group%20and%20centre%20across%20three%20screening%20cycles.%20A%20secondary%20analysis%20incorporated%20interval%20prostate%20cancer%20%28PCa%29%20cases-those%20diagnosed%20outside%20the%20screening%20protocol-among%20both%20ever-attenders%20and%20non-attenders.%20Incidence%20data%20from%20the%20control%20arm%20were%20included%20for%20comparison.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BRESULTS%3A%20Based%20on%20screen-detected%20cases%2C%20CDRs%20were%20consistently%20higher%20for%20low-grade%20than%20for%20intermediate-%20and%20high-grade%20cases%20across%20all%20centres%20and%20screening%20cycles.%20Trends%20in%20CDRs%20for%20high-grade%20cases%20varied%20by%20centre%3A%20CDRs%20decreased%20from%20the%20first%20to%20the%20second%20cycle%20and%20increased%20again%20during%20the%20third%20cycle%20in%20most%20centres%2C%20whereas%20CDRs%20increased%20in%20Spain%20with%20each%20successive%20screening%20cycle.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BCONCLUSION%3A%20The%20ERSPC%20data%20show%20a%20decreasing%20detection%20rate%20for%20low-grade%20cancer%20and%20substantial%20variation%20in%20the%20detection%20rate%20for%20intermediate-%20and%20high-grade%20cancer%20between%20centres%20across%20repeated%20screening%20rounds.%20Increasing%20interval%20and%20non-attender%20cancers%20indicate%20diminishing%20effectiveness%20of%20uniform%20screening%20schedules.%20These%20findings%20support%20personalised%20screening%20approaches%20and%20improved%20strategies%20to%20maintain%20participation.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42400346%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260707032721%26amp%3Bv%3D2.20.0%26quot%3B%26gt%3B42400346%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbju.70380%26quot%3B%26gt%3B10.1111%5C%2Fbju.70380%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-07-04%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fbju.70380%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42400346%5C%2F%3Futm_source%3DFirefox%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26fc%3D20241001055739%26ff%3D20260707032721%26v%3D2.20.0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-07-29T09%3A04%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22GJHP7D86%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kaipia%20et%20al.%22%2C%22parsedDate%22%3A%222026-07-04%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKaipia%2C%20A.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42400384%5C%2F%26%23039%3B%26gt%3BGeographical%20Pattern%20of%20Testicular%20Cancer%20Points%20to%20Maternal%20Exposures%20Behind%20Increasing%20Incidence%26lt%3B%5C%2Fa%26gt%3B.%20International%20Journal%20of%20Cancer.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Geographical%20Pattern%20of%20Testicular%20Cancer%20Points%20to%20Maternal%20Exposures%20Behind%20Increasing%20Incidence%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antti%22%2C%22lastName%22%3A%22Kaipia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karri%22%2C%22lastName%22%3A%22Sepp%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elli%22%2C%22lastName%22%3A%22Hirvonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eetu%22%2C%22lastName%22%3A%22M%5Cu00e4kinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nea%22%2C%22lastName%22%3A%22Malila%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janne%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorma%22%2C%22lastName%22%3A%22Toppari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Bostr%5Cu00f6m%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heikki%22%2C%22lastName%22%3A%22Seikkula%22%7D%5D%2C%22abstractNote%22%3A%22Evidence%20suggests%20that%20testicular%20cancer%20%28TC%29%20originates%20from%20germ%20cell%20neoplasia%20in%5Cu00a0situ%20arising%20during%20fetal%20development%2C%20implying%20that%20prenatal%20environmental%20exposures%20may%20influence%20disease%20risk.%20We%20investigated%20whether%20maternal%20place%20of%20residence%20during%20pregnancy%20is%20associated%20with%20regional%20variation%20in%20TC%20incidence.%20We%20conducted%20a%20nationwide%20cohort%20study%20including%201%2C342%2C996%20men%20born%20in%20Finland%20between%201960%20and%201999.%20Participants%20were%20followed%20from%20birth%20until%20diagnosis%20of%20TC%2C%20death%2C%20emigration%2C%20or%20the%20end%20of%20follow-up%20%282021%29.%20A%20total%20of%202976%20TC%20cases%20were%20identified.%20Information%20on%20municipality%20of%20birth%20was%20used%20as%20a%20proxy%20for%20maternal%20residence%20during%20pregnancy.%20Incidence%20rates%20and%20cumulative%20incidence%20were%20estimated%20by%20birth%20cohort%20and%20age%20at%20diagnosis.%20To%20examine%20regional%20variation%2C%20cumulative%20TC%20incidence%20by%20birth%20cohort%20and%20municipality%20was%20modeled%20using%20Bayesian%20hierarchical%20binomial%20regression%20allowing%20incidence%20to%20vary%20across%20municipalities.%20TC%20incidence%20increased%20across%20birth%20cohorts%2C%20peaking%20among%20men%20born%20in%201975-1979%20%2816.8%20per%20100%2C000%29.%20Cumulative%20incidence%20rose%20in%20all%20municipalities%2C%20ranging%20from%2067.9%20to%20132.5%20per%20100%2C000%20among%20men%20born%20in%201960-1969%20and%20from%20283.2%20to%20327.6%20among%20those%20born%20in%201980-1989.%20Marked%20geographic%20clustering%20was%20observed.%20Incidence%20was%20consistently%20elevated%20among%20men%20born%20in%20southwestern%20Finland%20and%20remained%20high%20throughout%20the%20study%20period.%20Over%20successive%20birth%20cohorts%2C%20an%20eastward%20shift%20in%20higher%20incidence%20was%20observed.%20Although%20direct%20cohort%20evidence%20linking%20specific%20environmental%20exposures%20to%20TC%20remains%20limited%2C%20these%20findings%20support%20the%20hypothesis%20that%20prenatal%20environmental%20factors%20contribute%20to%20the%20pathogenesis%20of%20TC%20and%20may%20partly%20explain%20regional%20differences%20in%20incidence.%22%2C%22date%22%3A%222026-07-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fijc.70636%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42400384%5C%2F%22%2C%22PMID%22%3A%2242400384%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221097-0215%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-07-29T09%3A04%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22KFS794U3%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22M%5Cu00e5nsson%20et%20al.%22%2C%22parsedDate%22%3A%222026-05-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BM%5Cu00e5nsson%2C%20M.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42205115%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260529040505%26amp%3Bv%3D2.20.0%26%23039%3B%26gt%3BComparison%20of%20the%20Swedish%20and%20Finnish%20Centers%20in%20the%20European%20Randomized%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29%26lt%3B%5C%2Fa%26gt%3B.%20European%20urology%20open%20science.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20the%20Swedish%20and%20Finnish%20Centers%20in%20the%20European%20Randomized%20Study%20of%20Screening%20for%20Prostate%20Cancer%20%28ERSPC%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22M%5Cu00e5nsson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirsi%22%2C%22lastName%22%3A%22Talala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anssi%22%2C%22lastName%22%3A%22Auvinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonas%22%2C%22lastName%22%3A%22Hugosson%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BEur%20Urol%20Open%20Sci.%202026%20May%2015%3B88%3A107-115.%20doi%3A%2010.1016%5C%2Fj.euros.2026.04.008.%20eCollection%202026%20Jun.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BBACKGROUND%20AND%20OBJECTIVE%3A%20The%20European%20Randomized%20Study%20of%20Screening%20for%20Prostate%20Cancer%20showed%2020%25%20reduction%20in%20prostate%20cancer%20%28PC%29%20mortality%20after%2016%20year%20follow-up%20of%20prostate-specific%20antigen%20%28PSA%29%20based%20screening%2C%20but%20effects%20varied%3A%209%25%20in%20Finland%20%28FinRSPC%29%20vs%2037%25%20in%20Sweden%20%28G%5Cu00f6teborg-1%29%20in%20screening%20vs%20control%20groups.%20The%20objective%20was%20to%20explore%20this%20difference.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BMETHODS%3A%20The%20data%20comprised%2064%20774%20participants%20in%20FinRSPC%20and%2010%20703%20men%20in%20G%5Cu00f6teborg-1%2C%20aged%2055-63%20year%20at%20randomization%20%28FinRSPC%3A%201996-1999%3B%20G%5Cu00f6teborg-1%3A%201995%29.%20Screening%20invitations%20were%20issued%20for%20PSA%20testing%20every%204%20year%2C%20with%20biopsy%20recommended%20if%20PSA%20%5Cu22654%20ng%5C%2Fml%2C%20or%203-3.99%20ng%5C%2Fml%20with%20an%20additional%20test%20in%20FinRSPC%3B%20and%20every%202%20year%2C%20with%20biopsy%20recommended%20at%20PSA%20%5Cu22653%20ng%5C%2Fml%20in%20G%5Cu00f6teborg-1.%20Expected%20incidence%5C%2Fmortality%20was%20based%20on%20registry%20data%20%281990-1994%2C%20and%202010-2014%29.%20Outcomes%20included%20cumulative%20PC%20incidence%2C%20PC-specific%20mortality%2C%20and%20relative%20risks.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BKEY%20FINDINGS%20AND%20LIMITATIONS%3A%20In%20G%5Cu00f6teborg-1%2C%20PC%20incidence%20was%2044%25%20higher%20%2895%25%20CI%20%5Bconfidence%20interval%5D%3A%2029-61%29%20and%20PC%20mortality%2036%25%20lower%20%2895%25%20CI%3A%207-56%29%20in%20screening%20vs%20control%20groups.%20In%20FinRSPC%2C%20PC%20incidence%20was%2021%25%20higher%20%2895%25%20CI%3A%2015-27%29%20and%20PC%20mortality%202%25%20lower%20%2895%25%20CI%3A%20-19-19%29.%20Screening%20groups%20in%20both%20centers%20had%20approximately%2040%25%20lower%20mortality%20than%20expected%20with%201990-1994%20rates%2C%20similar%20to%202010-2014%20rates.%20Swedish%20controls%20resembled%20expected%20rates%20in%201990-1994%20and%20Finnish%20controls%20in%202010-2014.%20A%20key%20limitation%20was%20the%20exploratory%20nature%20of%20the%20study.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BCONCLUSIONS%20AND%20CLINICAL%20IMPLICATIONS%3A%20The%20lower%20effect%20on%20PC%20mortality%20in%20FinRSPC%20appears%20attributable%20to%20unexpectedly%20low%20mortality%20in%20the%20control%20group%2C%20possibly%20due%20to%20extensive%20contamination%20from%20the%20start%20of%20the%20study.%20Findings%20highlight%20the%20challenges%20in%20demonstrating%20mortality%20benefit%20in%20screening%20trials%20under%20widespread%20opportunistic%20testing.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42205115%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260529040505%26amp%3Bv%3D2.20.0%26quot%3B%26gt%3B42205115%26lt%3B%5C%2Fa%26gt%3B%20%7C%20PMC%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2FPMC13202249%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260529040505%26amp%3Bv%3D2.20.0%26quot%3B%26gt%3BPMC13202249%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.euros.2026.04.008%26quot%3B%26gt%3B10.1016%5C%2Fj.euros.2026.04.008%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-05-28%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.euros.2026.04.008%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42205115%5C%2F%3Futm_source%3DFirefox%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26fc%3D20241001055739%26ff%3D20260529040505%26v%3D2.20.0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-05-29T08%3A05%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22DYTKFBCS%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22M%5Cu00e4kitie%20et%20al.%22%2C%22parsedDate%22%3A%222026-05-13%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BM%5Cu00e4kitie%2C%20R.E.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42126815%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260529040505%26amp%3Bv%3D2.20.0%26%23039%3B%26gt%3BOccupational%20Variation%20in%20Thyroid%20Cancer%20Incidence%20in%20the%20Nordic%20Countries%26lt%3B%5C%2Fa%26gt%3B.%20Oncology%20and%20therapy.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Occupational%20Variation%20in%20Thyroid%20Cancer%20Incidence%20in%20the%20Nordic%20Countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Riikka%20E.%22%2C%22lastName%22%3A%22M%5Cu00e4kitie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20I.%22%2C%22lastName%22%3A%22Martinsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanna%22%2C%22lastName%22%3A%22Lappi-Heikkinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johnni%22%2C%22lastName%22%3A%22Hansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elsebeth%22%2C%22lastName%22%3A%22Lynge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenny%22%2C%22lastName%22%3A%22Selander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingrid%20S.%22%2C%22lastName%22%3A%22Mehlum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f3hanna%20E.%22%2C%22lastName%22%3A%22Torfadottir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcin%20W.%22%2C%22lastName%22%3A%22Wojewodzic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rayan%22%2C%22lastName%22%3A%22Nikkil%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antti%22%2C%22lastName%22%3A%22M%5Cu00e4kitie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eero%22%2C%22lastName%22%3A%22Pukkala%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BOncol%20Ther.%202026%20May%2013.%20doi%3A%2010.1007%5C%2Fs40487-026-00438-7.%20Online%20ahead%20of%20print.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BINTRODUCTION%3A%20Although%20the%20rising%20worldwide%20incidence%20of%20thyroid%20cancer%20%28TC%29%20has%20been%20largely%20attributed%20to%20changes%20in%20diagnostic%20means%2C%20the%20full%20spectrum%20of%20contributing%20factors%20remains%20unknown.%20We%20present%20a%20comprehensive%20registry-based%20study%20evaluating%20the%20impact%20of%20occupational%20background%20on%20the%20risk%20of%20TC%20in%20the%20Nordic%20countries.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BMETHODS%3A%20Data%20were%20from%20the%20Nordic%20Occupational%20Cancer%20%28NOCCA%29%20study%20from%20the%20Nordic%20countries%20from%201961%20to%202005.%20Standardized%20incidence%20ratio%20%28SIR%29%20of%20TC%20in%20each%20occupational%20category%20was%20calculated%20using%20national%20incidence%20rates%20as%20reference.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BRESULTS%3A%20The%20NOCCA%20cohort%20includes%2014.9%20million%20people%20%287.5%20million%20women%20%2850.3%25%29%2C%207.4%20million%20men%20%2849.7%25%29%29.%20In%20total%2C%2023%2C241%20TCs%20were%20recorded%3A%2016%2C758%20%2871.9%25%29%20in%20women%20and%206483%20in%20men.%20Increased%20SIRs%20were%20observed%20in%20female%20farmers%20%28SIR%201.19%3B%2095%25%20CI%201.07-1.30%29%20and%20male%20fishermen%20%281.32%3B1.06-1.62%29%2C%20military%20personnel%20%281.29%3B%200.99-1.66%29%2C%20and%20clerical%20workers%20%281.19%3B%201.05-1.35%29.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20xmlns%3Axlink%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxlink%26quot%3B%20xmlns%3Amml%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1998%5C%2FMath%5C%2FMathML%26quot%3B%20xmlns%3Ap1%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fpubmed.gov%5C%2Fpub-one%26quot%3B%26gt%3BCONCLUSION%3A%20Our%20results%20suggest%20an%20association%20between%20certain%20occupational%20backgrounds%20and%20TC.%20These%20findings%20may%20help%20elucidate%20new%20risk%20factors%20for%20TC%20to%20enable%20targeted%20diagnosis%20and%20surveillance%20of%20individuals%20most%20at%20risk.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42126815%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260529040505%26amp%3Bv%3D2.20.0%26quot%3B%26gt%3B42126815%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs40487-026-00438-7%26quot%3B%26gt%3B10.1007%5C%2Fs40487-026-00438-7%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-05-13%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs40487-026-00438-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42126815%5C%2F%3Futm_source%3DFirefox%26utm_medium%3Drss%26utm_campaign%3Dpubmed-2%26utm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26fc%3D20241001055739%26ff%3D20260529040505%26v%3D2.20.0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-07-07T07%3A27%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22KXCPN7ZJ%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Carp%5Cu00e9n%20et%20al.%22%2C%22parsedDate%22%3A%222026-04-30%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCarp%5Cu00e9n%2C%20T.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42062661%5C%2F%26%23039%3B%26gt%3BOccupational%20Variation%20in%20the%20Incidence%20of%20Laryngeal%20Cancer%20in%20the%20Nordic%20Countries%26lt%3B%5C%2Fa%26gt%3B.%20Oncology%20and%20Therapy.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Occupational%20Variation%20in%20the%20Incidence%20of%20Laryngeal%20Cancer%20in%20the%20Nordic%20Countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timo%22%2C%22lastName%22%3A%22Carp%5Cu00e9n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zakarya%22%2C%22lastName%22%3A%22Hadj-Allal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rayan%22%2C%22lastName%22%3A%22Nikkil%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johnni%22%2C%22lastName%22%3A%22Hansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanna%22%2C%22lastName%22%3A%22Heikkinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elsebeth%22%2C%22lastName%22%3A%22Lynge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Ivar%22%2C%22lastName%22%3A%22Martinsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenny%22%2C%22lastName%22%3A%22Selander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingrid%20Sivesind%22%2C%22lastName%22%3A%22Mehlum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcin%20W.%22%2C%22lastName%22%3A%22Wojewodzic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f3hanna%20Eyr%5Cu00fan%22%2C%22lastName%22%3A%22Torfadottir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antti%22%2C%22lastName%22%3A%22M%5Cu00e4kitie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eero%22%2C%22lastName%22%3A%22Pukkala%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Laryngeal%20cancer%20%28LC%29%20constitutes%20almost%20one%20third%20of%20the%20head%20and%20neck%20cancers%2C%20and%20its%20main%20risk%20factors%2C%20alcohol%20use%20and%20smoking%2C%20are%20well%20established.%20Our%20aim%20was%20to%20explore%20the%20variation%20in%20the%20incidence%20of%20LC%20between%20different%20occupations.%5CnMETHODS%3A%20This%20study%20was%20based%20on%20data%20from%20the%20Nordic%20Occupational%20Cancer%20Study%20%28NOCCA%29%2C%20involving%2014.9%20million%20individuals%20from%20Denmark%2C%20Finland%2C%20Iceland%2C%20Norway%2C%20and%20Sweden.%20Occupational%20data%20from%20censuses%20were%20linked%20to%20cancer%20registry%20data%20from%20a%20period%20of%20up%20to%2045%5Cu00a0years%20%2821%2C166%20LC%20diagnoses%29%20using%20personal%20identity%20codes.%20Standardized%20incidence%20ratios%20%28SIRs%29%20were%20calculated%20for%20different%20occupations%2C%20using%20the%20respective%20national%20populations%20as%20a%20reference.%5CnRESULTS%3A%20Of%20the%2021%2C166%20patients%20with%20LC%2C%2018%2C488%20%2887%25%29%20were%20men.%20The%20highest%20SIRs%20in%20men%20were%20noted%20among%20waiters%20%283.31%2C%2095%25%20confidence%20interval%20%5BCI%5D%202.69-4.02%29%2C%20beverage%20workers%20%282.51%2C%2095%25%20CI%201.91-3.24%29%2C%20and%20cooks%20and%20stewards%20%282.25%2C%2095%25%20CI%201.82-2.74%29.%20Among%20women%2C%20the%20highest%20SIRs%20were%20observed%20among%20building%20hands%20%287.37%2C%2095%25%20CI%203.53-13.55%29%20and%20public%20safety%20workers%20%283.60%2C%2095%25%20CI%201.17-8.40%29.%20Farming%20and%20teaching%20occupations%20showed%20reduced%20SIRs%20in%20both%20sexes.%20The%20SIRs%20among%20male%20farmers%2C%20teachers%2C%20gardeners%2C%20and%20technical%20workers%20were%20reduced%20in%20all%20countries.%20The%20SIRs%20remained%20elevated%20and%20stable%20among%20cooks%20and%20stewards%2C%20waiters%2C%20packers%2C%20seamen%2C%20sales%20agents%2C%20and%20economically%20inactive%20males%20across%20the%20three%2015-year%20periods%20from%201961%20to%202005.%5CnCONCLUSION%3A%20The%20study%20confirms%20a%20major%20variation%20in%20the%20incidence%20of%20LC%20between%20occupations.%20The%20findings%20underscore%20the%20importance%20of%20considering%20lifestyle%20factors%20typical%20of%20each%20occupation%20in%20cancer%20risk%20assessments%20and%20the%20potential%20benefits%20of%20targeted%20prevention%20efforts.%22%2C%22date%22%3A%222026-04-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs40487-026-00436-9%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42062661%5C%2F%22%2C%22PMID%22%3A%2242062661%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222366-1089%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-07-07T07%3A27%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22ITANADGX%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Weiderpass%20et%20al.%22%2C%22parsedDate%22%3A%222026-04-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWeiderpass%2C%20E.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42008723%5C%2F%26%23039%3B%26gt%3BBridging%20science%20and%20action%3A%20celebrating%2060%20years%20of%20the%20IARC%20and%20looking%20ahead%26lt%3B%5C%2Fa%26gt%3B.%20Journal%20of%20the%20National%20Cancer%20Institute.%20Monographs.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bridging%20science%20and%20action%3A%20celebrating%2060%20years%20of%20the%20IARC%20and%20looking%20ahead%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabete%22%2C%22lastName%22%3A%22Weiderpass%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%5Cu00e9ronique%22%2C%22lastName%22%3A%22Chaj%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9ment%22%2C%22lastName%22%3A%22Chauvet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary%20K.%22%2C%22lastName%22%3A%22Schubauer-Berigan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joachim%22%2C%22lastName%22%3A%22Sch%5Cu00fcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorothy%22%2C%22lastName%22%3A%22Keefe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sirpa%22%2C%22lastName%22%3A%22Hein%5Cu00e4vaara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Young-Woo%22%2C%22lastName%22%3A%22Kim%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bdiv%20xmlns%3D%26quot%3Bhttp%3A%5C%2F%5C%2Fwww.w3.org%5C%2F1999%5C%2Fxhtml%26quot%3B%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20%234aa564%3B%26quot%3B%26gt%3BJ%20Natl%20Cancer%20Inst%20Monogr.%202026%20Apr%201%3B2026%2872%29%3A1-2.%20doi%3A%2010.1093%5C%2Fjncimonographs%5C%2Flgag002.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%26gt%3B%26lt%3Bb%26gt%3BNO%20ABSTRACT%26lt%3B%5C%2Fb%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bp%20style%3D%26quot%3Bcolor%3A%20lightgray%26quot%3B%26gt%3BPMID%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42008723%5C%2F%3Futm_source%3DFirefox%26amp%3Butm_medium%3Drss%26amp%3Butm_campaign%3Dpubmed-2%26amp%3Butm_content%3D1VcNN1T1QuuWzmJ8HqSJF3c-vw2MFgxTgtqNXnUUyEzTbu59Po%26amp%3Bfc%3D20241001055739%26amp%3Bff%3D20260422032313%26amp%3Bv%3D2.19.0.post6%2B133c1fe%26quot%3B%26gt%3B42008723%26lt%3B%5C%2Fa%26gt%3B%20%7C%20DOI%3A%26lt%3Ba%20href%3D%26quot%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjncimonographs%5C%2Flgag002%26quot%3B%26gt%3B10.1093%5C%2Fjncimonographs%5C%2Flgag002%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fp%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22date%22%3A%222026-04-20%2000%3A00%3A00%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fjncimonographs%5C%2Flgag002%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F42008723%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-05-13T06%3A04%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22WIKIAZ56%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Halme%20et%20al.%22%2C%22parsedDate%22%3A%222026-03-29%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHalme%2C%20A.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F41906334%5C%2F%26%23039%3B%26gt%3BSecond%20Malignant%20Neoplasms%20Following%20Treatment%20for%20Childhood%20Cancer%3A%20A%20Population-Based%20Registry%20Study%26lt%3B%5C%2Fa%26gt%3B.%20Acta%20Paediatrica.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Second%20Malignant%20Neoplasms%20Following%20Treatment%20for%20Childhood%20Cancer%3A%20A%20Population-Based%20Registry%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Halme%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Jokela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Hirvonen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Malila%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Pitk%5Cu00e4niemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hein%5Cu00e4vaara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20D.%22%2C%22lastName%22%3A%22Crompton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Diller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Madanat-Harjuoja%22%7D%5D%2C%22abstractNote%22%3A%22AIM%3A%20Improved%20survival%20after%20childhood%20cancer%20has%20led%20to%20a%20growing%20population%20at%20risk%20of%20second%20malignant%20neoplasms%20%28SMNs%29.%20This%20study%20assessed%20SMN%20risk%20and%20time%20trends%20among%20childhood%20cancer%20survivors%20in%20Finland.%5CnMETHODS%3A%20Data%20from%20the%20Finnish%20Cancer%20Registry%20included%2010%5Cu2009941%20patients%20diagnosed%20with%20cancer%20before%20age%2020%20between%201970%20and%202020.%20Patients%20were%20followed%20until%202021%20for%20SMN%20occurrence%20%28mean%20follow-up%2014.5%5Cu2009years%29.%20Standardised%20incidence%20ratios%20%28SIRs%29%20and%20absolute%20excess%20risks%20%28AERs%29%20were%20calculated.%20Trends%20were%20examined%20by%20comparing%20two%20diagnostic%20eras%3A%201970-1990%20and%201991-2020.%5CnRESULTS%3A%20Among%2010%5Cu2009941%20patients%2C%20498%20%284.6%25%29%20developed%20an%20SMN.%20The%20overall%20SIR%20was%204.41%20%2895%25%20CI%204.03-4.81%29.%20Patients%20diagnosed%20before%20age%2010%20had%20a%20significantly%20higher%20SMN%20risk%20%28SIR%206.79%2C%2095%25%20CI%205.92-7.76%29%20than%20those%20diagnosed%20at%20older%20ages%20%28SIR%203.47%2C%2095%25%20CI%203.07-3.90%3B%20p%5Cu2009%26lt%3B%5Cu20090.001%29.%20Survivors%20of%20central%20nervous%20system%20%28CNS%29%20and%20solid%20tumours%20diagnosed%20in%201991-2020%20had%20more%20than%20twice%20the%20SMN%20risk%20compared%20with%20those%20diagnosed%20in%201970-1990.%5CnCONCLUSIONS%3A%20SMN%20risk%20remains%20significant%20for%20childhood%20cancer%20survivors%2C%20particularly%20for%20CNS%20and%20solid%20tumour%20cases%2C%20highlighting%20the%20need%20for%20tailored%20surveillance%20and%20further%20research%20on%20the%20strategies%20to%20mitigate%20long-term%20adverse%20outcomes.%22%2C%22date%22%3A%222026-03-29%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fapa.70516%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F41906334%5C%2F%22%2C%22PMID%22%3A%2241906334%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221651-2227%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-05-13T06%3A04%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22TXLB8CUF%22%2C%22library%22%3A%7B%22id%22%3A1356613%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anniina%20et%20al.%22%2C%22parsedDate%22%3A%222026-03-24%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAnniina%2C%20K.%20et%20al.%20%282026%29%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F41873796%5C%2F%26%23039%3B%26gt%3BParental%20Socio-Economic%20Factors%20and%20the%20Risk%20of%20Invasive%20Bacterial%20Infections%20in%20Children%3A%20A%20Register-Based%20Finnish%20Study%26lt%3B%5C%2Fa%26gt%3B.%20Acta%20Paediatrica.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Parental%20Socio-Economic%20Factors%20and%20the%20Risk%20of%20Invasive%20Bacterial%20Infections%20in%20Children%3A%20A%20Register-Based%20Finnish%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyr%5Cu00f6nlahti%22%2C%22lastName%22%3A%22Anniina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermunen%22%2C%22lastName%22%3A%22Teemu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nieminen%22%2C%22lastName%22%3A%22Tea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koivisto%22%2C%22lastName%22%3A%22Karoliina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rantanen%22%2C%22lastName%22%3A%22Matti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sax%5Cu00e9n%22%2C%22lastName%22%3A%22Harri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madanat-Harjuoja%22%2C%22lastName%22%3A%22Laura%22%7D%5D%2C%22abstractNote%22%3A%22AIM%3A%20Little%20is%20known%20about%20how%20socio-economic%20factors%20influence%20severe%20childhood%20bacterial%20infections.%20We%20explored%20whether%20parental%20socio-economic%20status%20correlates%20with%20the%20risk%20of%20invasive%20bacterial%20infections%20in%20the%20offspring.%5CnMETHODS%3A%20Data%20on%20children%20%26lt%3B%5Cu200916%5Cu2009years%20with%20community-acquired%20blood%20or%20cerebrospinal%20fluid%20culture-positive%20bacterial%20infections%20during%202002-2016%20were%20collected%20from%20the%20National%20Infectious%20Diseases%20Register%20for%20the%20following%20pathogens%3A%20Streptococcus%20agalactiae%2C%20Staphylococcus%20aureus%2C%20Streptococcus%20pyogenes%2C%20Streptococcus%20pneumoniae%20and%20Escherichia%20coli.%20Statistics%20Finland%20randomly%20selected%20five%20age-%2C%20sex-%20and%20region-matched%20controls%20for%20cases%2C%20including%20data%20on%20parental%20income%20and%20education.%20Odds%20ratios%20%28ORs%29%20with%2095%25%20confidence%20intervals%20%2895%25%20CIs%29%20for%20invasive%20bacterial%20infections%20were%20estimated%20using%20logistic%20regression.%5CnRESULTS%3A%20The%20risk%20of%20severe%20bacterial%20infection%20was%20slightly%2C%20but%20not%20statistically%20increased%20with%20lowest%20parental%20income%20%28OR%201.09%2C%2095%25%20CI%200.94-1.26%29.%20This%20risk%20was%20more%20evident%20with%20Escherichia%20coli.%20Lower%20maternal%20education%20showed%20a%20slight%20trend%20towards%20increased%20risk%20of%20severe%20bacterial%20infections%20%28ORs%3A%20primary%20education%201.10%2C%2095%25%20Cl%200.97-1.24%3B%20secondary%20education%201.07%2C%2095%25%20Cl%200.98-1.17%29.%5CnCONCLUSION%3A%20Despite%20universal%20healthcare%20and%20a%20social%20welfare%20system%2C%20our%20data%20suggest%20that%20lower%20parental%20income%20and%20maternal%20education%20may%20be%20associated%20with%20a%20slightly%20increased%20risk%20of%20severe%20bacterial%20infections.%22%2C%22date%22%3A%222026-03-24%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fapa.70517%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubmed.ncbi.nlm.nih.gov%5C%2F41873796%5C%2F%22%2C%22PMID%22%3A%2241873796%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221651-2227%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-05-13T06%3A04%3A15Z%22%7D%7D%5D%7D
Leenen, R.C.A. et al. (2026) Prostate Cancer Mortality in Men not Attending a Population-based Screening Program: The “Good”, the “Bad”, and the “Ugly” After 20-yr Follow-up in the European Randomised study of Screening for Prostate Cancer. European Urology Open Science 91, 59–66.
Bhargava, S. et al. (2026) Interventions to increase breast cancer screening attendance among immigrants: a cross-sectional international survey. Journal of Public Health, fdag061.
Muhonen, E. et al. (2026) Incidence Trends of Colorectal Cancer by Social and Behavioral Factors-A Pooled Cohort Study. International Journal of Cancer.
Kallionpää, R.A. et al. (2026) Cancer incidence and the risk for multiple primary cancers in neurofibromatosis type 1. Journal of the National Cancer Institute, djag269.
Kyrönlahti, A. et al. (2026) Estimated number of children affected by paternal cancer diagnosis and death in Finland during 1970-2022: a population-based registry study. Acta oncologica (Stockholm, Sweden).
Pukkala, E. et al. (2026) Cancer incidence and mortality among persons in the Finnish Register of Employees Exposed to Carcinogens, 1979-2018. Annals of Work Exposures and Health 70(6), wxag062.
Tarkiainen, L. et al. (2026) Alcohol consumption increased the risk of prostate cancer: A Finnish pooled population-based cohort study. European journal of cancer (Oxford, England : 1990).
Pasanen, N. et al. (2026) Cancer detection in the European Randomised Study of Screening for Prostate Cancer (ERSPC). BJU international.
Kaipia, A. et al. (2026) Geographical Pattern of Testicular Cancer Points to Maternal Exposures Behind Increasing Incidence. International Journal of Cancer.
Månsson, M. et al. (2026) Comparison of the Swedish and Finnish Centers in the European Randomized Study of Screening for Prostate Cancer (ERSPC). European urology open science.
Mäkitie, R.E. et al. (2026) Occupational Variation in Thyroid Cancer Incidence in the Nordic Countries. Oncology and therapy.
Carpén, T. et al. (2026) Occupational Variation in the Incidence of Laryngeal Cancer in the Nordic Countries. Oncology and Therapy.
Weiderpass, E. et al. (2026) Bridging science and action: celebrating 60 years of the IARC and looking ahead. Journal of the National Cancer Institute. Monographs.
Halme, A. et al. (2026) Second Malignant Neoplasms Following Treatment for Childhood Cancer: A Population-Based Registry Study. Acta Paediatrica.
Anniina, K. et al. (2026) Parental Socio-Economic Factors and the Risk of Invasive Bacterial Infections in Children: A Register-Based Finnish Study. Acta Paediatrica.

Cancer i Finland

Articles about Cancer i Finland. Read the whole publication here.